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KMID : 0360319870190010028
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Journal of Korean Cancer Research Association
1987 Volume.19 No. 1 p.28 ~ p.36
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Effects of Copolang on Murine Immune Function and Antitumor Activity
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조성기/Jo, Sung-Kee
김성호/윤택구/Kim, Sung-Ho/Yun, Taik-Koo
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Abstract
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The examinations were conducted with Copolang (protein bound polysaccharides from natural Coriolus versicolor) and PSK(protein bound polysaccharides from cultured Coriolus versicolor) referring to anti-tumor effect on several experimental tumor lines, influence on host immune function and its toxicity.
Acute toxicity of Copolang could not be observed because the case of death was occured at higher dose administrations.
There were significant inhibition of tumor growth in Sarcoma 180 by intraperitoneal administration of Copolang or PSK compared with control(p<0.01). Two cases of complete tumor regression was observed in the Copolang or PSK , treatment group. However, the results indicated that Copolang or PSK did not inhibit the growth of L1210 solid tumor and not prolonged life span of L1210 or P 388 tumor bearing mice.
Natural killer cell activities of splenic lymphocytes and non-adherent peritoneal exudate cells were augmented by Copolang administration in EL-4 transplanted C5; BL/6 mice. Cvtotoxicitv of T lymphocyte against EL-4 was enhanced by Copolang in the tumor bearing mice.
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